Endocrine Abstracts

Background: Parathyroid adenomas form a major proportion (80-85%) of the causative pathology in primary hyperparathyroidism (PHPT) followed by hyperplasia (10-15%) and cancers <1%. The only definitive treatment option for PHPT is surgery.Aim: To determine the pickup rate and correlation of the imaging modalities (ultrasound (US) and Sestamibi (MIBI)) with histological diagnosis of parathyroid adenomas in patients with PHPTMetho...

AimTo assess relationship between serum calcium level and localization studies and management outcome.MethodologyRetrospective analysis of data for patients referred by primary care for hypercalcemia from 1/3/2019 to 1/3/2020 to the Endocrinology department at Royal Berkshire Hospital. The sample size was 63 which excluded normo-calcemic hyperparathyroidism as well as MEN1/2 patients.Re...

Steroid replacement is life-saving in patients with steroid axis deficiency; education surrounding steroid replacement is vital in their management.We organised ‘Steroid Replacement Education Days’ for patients and their family members/carers to help enhance their knowledge on steroids and intercurrent illness. Lectures detailed manifestations, causes, management of steroid deficiency and the practical issues surrounding steroid replacement. Th...

Background: TSH-receptor stimulating antibodies are implicated in the pathophysiology of Graves’ disease (GD). The detection of TSH-receptor antibodies (TSHR-Abs) is routinely performed by assays measuring thyrotropin-binding inhibitor immunoglobulin and new generation assays are reported to have high sensitivity and specificity in GD. The differentiation of hyperthyroidism (GD or toxic multinodular goiter (TMG) or toxic adenoma (TA)) is important for planning the therapy...

Turner syndrome results from the complete or partial lack of one X chromosome and occurs in approximately 1:2500 female live births. The incidence of spontaneous puberty in the 45, X karyotype is about 9%. Spontaneous pregnancy has been reported in less than 5% of the cases, the majority of which have been described in subjects with mosaicism; these are often associated with high rates of miscarriage and stillbirth.A 51-year-old check-out supervisor was ...

Background: Turner syndrome (TS) affects 1:2500 live births. Mean age of death is reported 27.9±25.5 years due to cardiovascular complications. Expert care is required for better outcome.Aim: To review data on presentation and follow-up of a large series of patients with TS attending our Adult TS clinic.Patients and methods: The records of 64 out of 72 patients were available for review.Results: About 56...

Introduction: Obesity is a global problem and its prevalence is on the rise in the U.K. It is associated with multiple co-morbidities with high mortality and has significant impact on healthcare costs. Bariatric surgery in recent past has revolutionized obesity treatment.Aims: To assess effectiveness of bariatric surgery in terms of metabolic outcomes in patients with obesity in a single center in the UK.Methods: Retrospective anal...